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Robotic Bronchoscopy With CBCT Image Fusion for Pulmonary Nodule Diagnosis in People Living With HIV
NCT07663656 · wu qingguo · Updated 23 June 2026
- What is being tested
- Robotic bronchoscopy with CBCT-guided multimodal image fusion and targeted cryobiopsy; Electromagnetic navigation bronchoscopy with radial EBUS and targeted cryobiopsy
- For
- HIV Infections; Pulmonary Nodule
- Kind of study
- Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
- Who can join
- Ages 18 years to 70 years. About 100 people. The full rules are on the registry page.
- Where
- Not stated
- When
- Starts or started July 2026, ends March 2028. Registered 23 June 2026.
- Results
- None posted yet.
In the researchers' words
This multicenter study evaluates a full-situational awareness robotic bronchoscopy system combined with CBCT-based multimodal image fusion for diagnosing lung nodules in people living with HIV (PLWH). Lung nodules are small lesions that may be benign or cancerous. In PLWH, accurate diagnosis is especially important but challenging. In this study, participants will be assigned to one of two groups: * Experimental group: Robotic bronchoscopy with real-time full-situational awareness and CBCT image fusion; * Control group: Electromagnetic navigation-guided bronchoscopy combined with radial endobronchial ultrasound (EBUS). In both groups, rapid on-site cytologic evaluation (ROSE) will be performed to confirm tissue adequacy. For participants confirmed to have lung cancer and meeting safety criteria, an exploratory transbronchial cryoablation will be performed during the same procedure. The study aims to compare diagnostic accuracy and safety between the two approaches and to explore the feasibility of immediate cryoablation for early-stage lung cancer in PLWH.