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By invitation only

The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rectal Cancer

NCT07376980 · Korea University Anam Hospital · Updated 29 Jan 2026

What is being tested
Modified single-stapled anastomosis technique
For
Rectal Neoplasms; Rectal Neoplasms Malignant; Rectal Cancer; Rectal Cancer Surgery
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 19 years and older. About 450 people. The full rules are on the registry page.
Where
South Korea (6 sites)
When
Starts or started 20 Dec 2025, ends 30 Dec 2030. Registered 29 Jan 2026.
Results
None posted yet.

In the researchers' words

The goal of this clinical trial is to learn whether a modified single-stapled anastomosis (MST) can reduce anastomotic leakage compared with the conventional double-stapled technique (DST) in adult patients undergoing laparoscopic or robotic low anterior resection for rectal cancer. The main questions it aims to answer are: * Does MST lower the incidence of anastomotic leakage after rectal cancer surgery? * Does MST improve short-term surgical outcomes compared with DST? Researchers will compare the MST group with the DST group to see if MST leads to fewer anastomotic leaks and safer postoperative recovery. Participants will: Receive either MST or DST during minimally invasive rectal cancer surgery Undergo routine postoperative CT scans within one month after surgery to check for symptomatic or asymptomatic anastomotic leakage Attend scheduled follow-up visits and standard postoperative assessments as part of routine rectal cancer care
ClinicalTrials.gov, NCT07376980

Sites

  • St. Vincent's HospitalSuwon, Gyeonggi-do, South Korea
  • Kyungpook National University Chilgok HospitalDaegu, Gyeongsangbuk-do, South Korea
  • Kyung Hee University HospitalSeoul, South Korea
  • Korea University Anam HospitalSeoul, South Korea
  • Seoul National University HospitalSeoul, South Korea
  • Severance HospitalSeoul, South Korea