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Robot/Laparoscopic-Assisted Transanal Transection Duhamel Versus Modified Soave Pull-Through for TCA

NCT07343622 · Zunyi Medical College · Updated 15 Jan 2026

What is being tested
Transanal Transection Duhamel operation; Modified Soave Pull-Through
For
Total Colonic Aganglionosis; Hirschsprung Disease; Duhamel; Soave
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 1 Month to 14 years. About 50 people. The full rules are on the registry page.
Where
China
When
Starts or started 30 Jan 2026, ends 31 Dec 2027. Registered 15 Jan 2026.
Results
None posted yet.

In the researchers' words

Total colonic Hirschsprung disease (TCA) is the most severe form of Hirschsprung disease and is commonly managed with neonatal enterostomy followed by delayed definitive pull-through. Despite widespread use, the optimal reconstructive procedure for TCA remains uncertain. The Duhamel and modified Soave pull-through procedures are the two most frequently adopted techniques, each with distinct theoretical advantages and limitations regarding bowel function, enterocolitis risk, and anorectal physiology. With the increasing application of minimally invasive and robot-assisted surgery, both procedures have been further refined; however, robust comparative evidence, particularly for total colonic disease, is lacking. To date, no multicenter study has provided a detailed comparison of postoperative functional outcomes and Hirschsprung-associated enterocolitis between transanal transection Duhamel and modified Soave procedures. This multicenter study compares robot-assisted transanal transection Duhamel and modified Soave pull-through in patients with pathologically confirmed TCA after neonatal enterostomy, focusing on postoperative bowel function and enterocolitis incidence.
ClinicalTrials.gov, NCT07343622

Sites

  • Affiliated Hospital of Zunyi Medical UniversityZunyi, Guizhou, China