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Effect of Topical Lidocaine Spraying on the Vocal Cords Before Intubation During Robotic Surgery: a Randomized Controlled Trial

NCT07154628 · Kaohsiung Medical University Chung-Ho Memorial Hospital · Updated 11 Sept 2025

What is being tested
Lidocaine %2 ampoule; Normal Saline (0.9% NaCl)
For
Lidocaine Spray; Intubation; Robotic Surgery
Kind of study
Tests a treatment or device on volunteers. Phase 4.
Who can join
Ages 18 years to 69 years. About 80 people. The full rules are on the registry page.
Where
Taiwan
When
Starts or started 1 Sept 2025, ends 31 Dec 2028. Registered 4 Sept 2025.
Results
None posted yet.

In the researchers' words

Endotracheal intubation is a respiratory management technique used during general anesthesia. It is essential for certain surgical procedures as it ensures a secure airway for the patient. However, during the placement of the endotracheal tube, the passage of the tube through the vocal cords can cause pain stimulation, leading to an increase in heart rate and blood pressure. Lidocaine reversibly blocks the conduction of nerve impulses along nerve fibers by preventing the movement of sodium ions across the nerve membrane. Topical application of lidocaine near the vocal cords before endotracheal tube placement may be a way to reduce the surgical pleth index and changes in vital signs (heart rate, blood pressure) caused by excessive endotracheal tube stimulation. This study aims to investigate the benefit of topical spraying of lidocaine on the vocal cords before endotracheal tube placement during routine da Vinci surgery. The primary outcomes were the pharmacological effects of spraying either lidocaine or normal saline (control group) on the vocal cords. These included: post-intubation hypertension (defined as an increase in systolic blood pressure of more than 20% from baseline), changes in mean arterial pressure before and after intubation, and objective pain indices such as the Surgical Pleth Index. Secondary outcomes included post-intubation hypotension (defined as mean…
ClinicalTrials.gov, NCT07154628

Sites

  • Kaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung City, Taiwan