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Application of the "Off-Clamp And Sutureless" Technique in Robot-Assisted Partial Nephrectomy

NCT07141225 · Shao Pengfei · Updated 5 Sept 2025

What is being tested
Off-Clamp Sutureless Technique
For
Renal and Urinary Disorders; Renal Cancer; Renal Particial
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years to 80 years. About 190 people. The full rules are on the registry page.
Where
China
When
Starts or started 1 June 2025, ends 30 June 2028. Registered 26 Aug 2025.
Results
None posted yet.

In the researchers' words

The detection rate of renal masses smaller than 7 cm has significantly increased in recent years. To preserve postoperative renal function to the greatest extent possible, guidelines from the European Association of Urology (EAU), the National Comprehensive Cancer Network (NCCN), and others have endorsed partial nephrectomy (PN) as the preferred treatment strategy for small renal masses. In conventional PN, it is necessary to clamp the renal artery or its branch arteries and employ a double-layer suturing technique to close the resection bed. This controls bleeding, maintains a clear surgical field, and prevents postoperative urinary leakage. The maximum safe duration of warm ischemia to avoid irreversible renal parenchymal damage remains controversial, though most studies indicate a window of 20-30 minutes. Consequently, the "off-clamp sutureless" concept has gained prominence. Its core principle is to avoid renal artery clamping and replace suturing with novel haemostatic techniques, thereby maximizing the preservation of healthy renal parenchyma. With the diversification of haemostatic material options and the widespread adoption of robotic-assisted systems, the off-clamp sutureless strategy has become technically feasible for small renal masses with low complexity . Multiple retrospective studies demonstrate that the off-clamp sutureless technique is non-inferior,…
ClinicalTrials.gov, NCT07141225

Sites

  • The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)Nanjing, Jiangsu, China