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Pre-Op MRI on Margin Status for Transoral Robotic Surgery for HPV+ Tonsillar Squamous Cell Carcinoma
NCT07060261 · Case Comprehensive Cancer Center · Updated 22 Sept 2026
- What is being tested
- Transoral robotic surgery+MRI
- For
- Human Papilloma Virus Related Carcinoma; Tonsillar Squamous Cell Carcinoma
- Kind of study
- Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
- Who can join
- Ages 18 years and older. About 30 people. The full rules are on the registry page.
- Where
- United States
- When
- Starts or started 26 Nov 2025, ends Dec 2026. Registered 11 July 2025.
- Results
- None posted yet.
In the researchers' words
This prospective research study aims to see if pre-operative MRI can predict the margin status after transoral robotic surgery (TORS) for human papillomavirus positive (HPV+) tonsillar squamous cell carcinoma (SCC). The pre-operative MRI will have a standard MR neck without and with contrast, with added axial T2 weighted sequence and T2 SPACE sequence through the tonsils. Three neuroradiologists will grade the thickness of the pharyngeal constrictor muscle (the muscle that surrounds the tonsils) on a five-point scale. The study will determine if the pre-operative MRI grading will correlate with positive, insecure (\<1mm), or secure (\>1mm) margin during TORS surgery for your HPV+ tonsillar SCC.
Sites
- Case Comprehensive Cancer Center, Cleveland Clinic FoundationCleveland, Ohio, United States