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The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition
NCT06865027 · University Hospital, Akershus · Updated 2 June 2026
- What is being tested
- Ventilation strategy
- For
- Intracranial Pressure; Circulation System; Cerebral Perfusion Pressure; Cognitive Function
- Kind of study
- Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
- Who can join
- Ages 55 years to 80 years. About 46 people. The full rules are on the registry page.
- Where
- Norway
- When
- Starts or started 24 Jan 2025, ends 28 May 2026. Registered 7 March 2025.
- Results
- None posted yet.
In the researchers' words
Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood. This will be managed by applying different ventilation strategies during anesthesia.The levels will be distinctly different. The investigators will assess whether different concentrations of carbon dioxide in blood results in different brain blood flow levels and different intracranial pressure during laparascopic surgery in the head-down tilted position. The investigators also will assess if different carbon dioxide level will manifest in different cognitive abilities in the two study groups, measured on day 1 post-surgery.
Sites
- Akershus University HospitalLørenskog, Norway