Looking for volunteers
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
NCT06747390 · Ryan Carey · Updated 12 May 2026
- What is being tested
- Lidocaine 1% Injectable Solution
- For
- Oropharyngeal Squamous Cell Carcinoma (OPSCCA); Oropharyngeal Cancer; Human Papilloma Virus; Squamous Cell Carcinoma
- Kind of study
- Tests a treatment or device on volunteers. Phase 1.
- Who can join
- Ages 18 years and older. About 30 people. The full rules are on the registry page.
- Where
- United States
- When
- Starts or started 23 April 2025, ends 1 Nov 2028. Registered 24 Dec 2024.
- Results
- None posted yet.
In the researchers' words
Based on evidence that the local anesthetic lidocaine may have anticancer effects, this study will assess the safety and efficacy of intratumoral lidocaine injection at the time of direct laryngoscopy prior to TransOral Robotic Surgery (TORS) and neck dissection for oropharyngeal squamous cell carcinoma (OPSCC). The primary objective of the study is to determine if intratumoral lidocaine injection is safe and causes a major pathologic treatment effect in the primary tumor following surgical resection. The secondary objectives will be to determine if intratumoral lidocaine injection improves locoregional control rates, progression-free survival, metastasis-free survival, and overall survival compared to no injection.
Sites
- Abramson Cancer Center at University of PennsylvaniaPhiladelphia, Pennsylvania, United States