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Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease

NCT06602544 · Harvard Medical School (HMS and HSDM) · Updated 18 July 2025

What is being tested
Robotic Apparel
For
Parkinson Disease (PD)
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years to 90 years. About 20 people. The full rules are on the registry page.
Where
United States (2 sites)
When
Starts or started 3 Sept 2024, ends Sept 2027. Registered 19 Sept 2024.
Results
None posted yet.

In the researchers' words

Freezing-of-gait (FoG) in Parkinson Disease (PD) is one of the most vivid and disturbing gait phenomena in neurology. Often described by patients as a feeling of "feet getting glued to the floor," FoG is formally defined as a "brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk." This debilitating gait phenomena is very common in PD, occurring in up to 80% of individuals with severe PD. When FoG arrests walking, serious consequences can occur such as loss of balance, falls, injurious events, consequent fear of falling, and increased hospitalization. Wearable robots are capable of augmenting spatiotemporal gait mechanics and are emerging as viable solutions for locomotor assistance in various neurological populations. For the proposed study, our goal is to understand how low force mechanical assistance from soft robotic apparel can best mitigate gait decline preceding a freezing episode and subsequent onset of FoG by improving spatial (e.g. stride length) and temporal features (e.g. stride time variability) of walking. We hypothesize that the ongoing gait-preserving effects can essentially minimize the accumulation of motor errors that lead to FoG. Importantly, the autonomous assistance provided by the wearable robot circumvents the need for cognitive or attentional resources, thereby minimizing risks for overloading the…
ClinicalTrials.gov, NCT06602544

Sites

  • Harvard Science and Engineering ComplexAllston, Massachusetts, United States
  • Boston University Sargent College of Health and Rehabilitation SciencesBoston, Massachusetts, United States