Monday, October 26, 2026 · Daily editionET --:--:--

Finished

Comparison of Volume-controlled and Pressure-controlled Ventilation in Clasp-knife Position

NCT06056401 · Sun Yat-sen University · Updated 28 Sept 2023

What is being tested
record Hemodynamic variables, respiratory variables and arterial blood gas at specific times
For
Mechanical Ventilation; General Anesthesia; Urological Surgery; Robotic Surgery
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years to 65 years. About 60 people. The full rules are on the registry page.
Where
China
When
Starts or started 15 Oct 2022, ends 24 Feb 2023. Registered 28 Sept 2023.
Results
None posted yet.

In the researchers' words

Carbon dioxide (CO2) pneumoperitoneum and clasp-knife positioning are commonly used to improve surgical access during robot-assisted laparoscopic urological surgery. However, these methods are sometimes associated with several unwanted cardiopulmonary effects such as increased mean arterial pressure, decreased pulmonary compliance and functional residual capacity, increased peak inspiratory pressure, and respiratory acidosis in association with hypercarbia. Volume-controlled ventilation (VCV) is the most commonly used method of ventilation during general anesthesia. It provides fixed minute ventilation and pulmonary resistance, which affect airway pressure. In pressure-controlled ventilation (PCV), constant inspiratory airway pressure can be achieved by decelerating the flow. However, minute ventilation is not fixed . CO2 pneumoperitoneum in the clasp-knife positioning can influence hemodynamic variables, including blood pressure, heart rate, and cardiac output. This is because changes in airway pressure affect intrathoracic pressure and the function of the heart itself. In this randomized study, we investigated the effects of VCV and PCV on peak inspiratory pressure during robot-assisted laparoscopic urological surgery involving CO2 pneumoperitoneum in the clasp-knife position.
ClinicalTrials.gov, NCT06056401

Sites

  • Cai XinyuanGuangzhou, Guangdong, China