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HFLVV for Hypoxemia in Robot-assisted Cardiac Surgery

NCT04926649 · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Updated 15 June 2021

What is being tested
Differential ventilation to the non-dependent lung
For
Hypoxemia
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years to 70 years. About 56 people. The full rules are on the registry page.
Where
China
When
Starts or started 1 June 2021, ends 15 March 2022. Registered 15 June 2021.
Results
None posted yet.

In the researchers' words

These robot-assisted cardiac surgeries usually require single-lung ventilation (SLV) to facilitate surgical exposure. SLV creates ventilation/perfusion mismatch and shunt (Qs:Qt) through the collapsed lung and leads to hypoxemia. Pulmonary gas exchange often deteriorates after cardiopulmonary bypass (CPB) because of ischemic tissue damage. In some cases, severe hypoxemia may require the cessation of surgical procedures and the initiation of double-lung ventilation to improve oxygenation. In this study, the investigator applied the continuous positive airway pressure (CPAP) or the high-frequency low-volume ventilation (HFLVV) to the non-dependent lung (differential ventilation) during the weaning from CPB. The investigator hypothesized that the differential ventilation would produce the least interference with the surgeon's exposure and better oxygenation. The investigators evaluate the airway pressure, shunt fraction, PaO2/FiO2, cerebral oximetry, surgical field condition and the length of stay in intensive care unit of patients underwent the robot-assisted cardiac surgery.
ClinicalTrials.gov, NCT04926649

Sites

  • Daping Hospital, Army Medical UniversityChongqing, Chongqing Municipality, China