Monday, October 26, 2026 · Daily editionET --:--:--

Paused

Real-time Neuromuscular Control of Exoskeletons

NCT04661891 · Shirley Ryan AbilityLab · Updated 14 July 2026

What is being tested
Isometric contractions; Isokinetic contractions; Dynamic contractions; Isometric contraction with muscle fatigue; Multi-joint functional activities while wearing exoskeleton; Clinical Assessments
For
Stroke
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years to 80 years. About 80 people. The full rules are on the registry page.
Where
United States
When
Starts or started 5 May 2021, ends 15 July 2026. Registered 10 Dec 2020.
Results
None posted yet.

In the researchers' words

The purpose of this study is to develop a real-time controller for exoskeletons using neural information embedded in human musculature. This controller will consist of an online interface that anticipates human movement based on high-density electromyography (HD-EMG) recordings, and then translates it into functional assistance. This study will be carried out in both healthy participants and participants post-stroke. The researchers will develop an online algorithm (decoder) in currently existing exoskeletons that can extract hundreds of motor unit (MU) spiking activity out of HD-EMG recordings. The MU spiking activity is a train of action potentials coded by its timing of occurrence that gives access to a representative part of the neural code of human movement. The researchers will also develop a command encoder that can anticipate human intent (multi-joint position and force commands) from MU spiking activity to translate the neural information to movement. The researchers will integrate the decoder with the command encoder to showcase the real-time control of multiple joint lower-limb exoskeletons.
ClinicalTrials.gov, NCT04661891

Sites

  • Shirley Ryan AbilityLabChicago, Illinois, United States