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Feasibility of Neural Feedback for Lower Limb Amputees

NCT03409133 · Louis Stokes VA Medical Center · Updated 6 March 2026

What is being tested
Stimulating nerve electrodes and intramuscular recording electrodes
For
Amputation
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years and older. About 15 people. The full rules are on the registry page.
Where
United States
When
Starts or started 5 Nov 2015, ends 1 Sept 2027. Registered 24 Jan 2018.
Results
None posted yet.

In the researchers' words

The purpose of this study is to evaluate the effectiveness of providing sensation of the missing limb to individuals with lower limb loss, including above and below knee amputees. The approach involves delivering small electrical currents directly to remaining nerves via implanted stimulating electrodes. These small electrical currents cause the nerves to generate signals that are then transferred to your brain similar to how information about the foot and lower limb used to be transferred to your brain prior to the amputation. Individuals also have the option to have recording electrodes implanted within muscles of the lower limb(s) in an attempt to develop a motor controller that would enable the user to have intuitive control of a robotic prosthetic leg.
ClinicalTrials.gov, NCT03409133

Sites

  • Louis Stokes VA Medical CenterCleveland, Ohio, United States