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Under way, not recruiting

Evaluating the Effects of Frozen Section Technology on Oncological and Functional Outcomes at Radical Prostatectomy.

NCT03317990 · University College, London · Updated 4 Sept 2025

What is being tested
NeuroSAFE procedure; Standard RARP
For
Prostate Cancer
Kind of study
Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
Who can join
Ages 18 years to 75 years. About 407 people. The full rules are on the registry page.
Where
United Kingdom (5 sites)
When
Starts or started 9 April 2018, ends Dec 2027. Registered 23 Oct 2017.
Results
Posted on the registry on 4 Sept 2025.

In the researchers' words

In summary this trial will test whether this new surgical technique can be used to make surgery safer and more effective whilst allowing improved quality of life for patients having surgery for prostate cancer. If the technique is proven effective the investigators will use the experience gained to promote its use throughout the NHS through training courses and publication and dissemination of the resultant data. Staff from centres participating in this trial will be fully trained in the NeuroSAFE technique. A patient and public involvement afternoon was held for participants of the NeuroSAFE PROOF feasibility study, family members, men with prostate cancer, and staff members at UCLH. The event was supported by the charity Orchid Cancer appeal. The high levels of attendance was demonstrative of the support within our patient group for the work of this trial. The trial team listened to the comments made by participants and members of the public and have made some changes to the design of our trial as a result of this feedback.
ClinicalTrials.gov, NCT03317990

Sites

  • North Bristol NHS TrustBristol, United Kingdom
  • NHS Greater Glasgow & ClydeGlasgow, United Kingdom
  • University College London HospitalLondon, United Kingdom
  • Nottingham University HospitalsNottingham, United Kingdom
  • Sheffield Teaching Hospitals NHS Foundation TrustSheffield, United Kingdom