Finished
Effect of Ramosetron on Heart Rate-corrected QT Interval During Robot-assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position
NCT03232125 · Yonsei University · Updated 25 Aug 2020
- What is being tested
- Ramosetron; Normal saline
- For
- Prostate Cancer
- Kind of study
- Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
- Who can join
- Ages 20 years to 80 years. About 54 people. The full rules are on the registry page.
- Where
- South Korea
- When
- Starts or started 1 Aug 2017, ends 12 June 2020. Registered 27 July 2017.
- Results
- None posted yet.
In the researchers' words
Intraperitoneal insufflation of carbon dioxide may affect the sympathetic activity that leads to changes in ventricular re-polarization. This in turn can result in changes of heart rate-corrected QT (QTc) interval. Ramosetron is a 5-hydroxytryptamine three receptor antagonist and widely used anti-emetics. However, QTc interval prolongation has been observed in a number of patients after administration of 5-HT3 receptor antagonists. The aim of this study is to evaluate the effects of ramosetron on QTc interval and possible cardiovascular adverse effects during robot-assisted laparoscopic prostatectomy with steep Trendelenburg position.
Sites
- Professor, Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of MedicineSeoul, South Korea