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The Effect of Different Doses of Remifentanil on Kidney Function During Robot Assisted Prostatectomy - A Retrospective Study
NCT02041559 · Yonsei University · Updated 22 Jan 2014
- What is being tested
- Not stated
- For
- Prostate Cancer
- Kind of study
- Watches patients without assigning a treatment. No drug phase (a device or procedure study).
- Who can join
- Ages 20 years to 85 years. About 1,500 people. The full rules are on the registry page.
- Where
- South Korea
- When
- Starts or started Jan 2014, ends Dec 2014. Registered 22 Jan 2014.
- Results
- None posted yet.
In the researchers' words
Robot assisted prostatectomy reduces the patients' postoperative pain and leads to rapid rehabilitation. But pneumoperitoneum affects the kidney. The increase of stress hormone reduces the glomerular filtration and the vaso-contraction of renal vessels leads the renal ischemia. Remifentanil is analgesics coupled with μ opioid receptor. In high dose of remifentanil, it is associated with κ and δ receptors, which leads to renal protection effect in animal study. Also, remifentanil infusion during anesthesia showed a diuretic effect. The purpose of this study is to investigate the remifentanil effect on renal function during robot assisted prostatectomy.
Sites
- Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University Health SystemSeoul, South Korea