Status not kept up to date
Oxidative Stress in Robot-assisted Laparoscopic Radical Prostatectomy
NCT01334424 · Chang Gung Memorial Hospital · Updated 13 April 2011
- What is being tested
- propofol
- For
- Oxidative Stress
- Kind of study
- Tests a treatment or device on volunteers. No drug phase (a device or procedure study).
- Who can join
- Ages 20 years to 80 years. About 40 people. The full rules are on the registry page.
- Where
- Taiwan
- When
- Starts or started Dec 2009, ends April 2011. Registered 13 April 2011.
- Results
- None posted yet.
In the researchers' words
Gut hypoperfusion - reperfusion injury is an unavoidable event at the end of laparoscopic surgery. It produces oxidative stress (reactive oxygen species). Malondialdehyde have been demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo. Propofol (2, 6 - diisopropylphenol), a highly liposoluble anaesthetic, has a potent antioxidant activity against lipid peroxidation in both in vitron and in vivo studies. On the basis of this knowledge, the investigators hypothesized that propofol has preventive effect for gut hypoperfusion - reperfusion induced injury in robot-assisted laparoscopic radical prostatectomy.
Sites
- Dept. of Anesthesiology, Chang Gung Memorial HospitalTaoyuan, Taiwan